Blar i forfatter "Nthiga, Thaddaeus Mutugi"

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    • CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Sjøttem, Eva; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)
      The endoplasmic reticulum (ER) plays important roles in protein synthesis and folding, and calcium storage. The volume of the ER and expression of its resident proteins are increased in response to nutrient stress. ER‐phagy, a selective form of autophagy, is involved in the degradation of the excess components of the ER to restore homeostasis. Six ER‐resident proteins have been identified as ER‐phagy ...

    • NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy 

      Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-11)
      The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their recognition and targeting by mitophagy is limited. Here, we show that the mitochondrial matrix proteins 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog ...

    • Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)
      The Golgi complex is essential for the processing, sorting, and trafficking of newly synthesized proteins and lipids. Golgi turnover is regulated to meet different cellular physiological demands. The role of autophagy in the turnover of Golgi, however, has not been clarified. Here we show that CALCOCO1 binds the Golgi-resident palmitoyltransferase ZDHHC17 to facilitate Golgi degradation by autophagy ...

    • Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy 

      Nthiga, Thaddaeus Mutugi (Doctoral thesis; Doktorgradsavhandling, 2020-02-20)
      Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...

    • The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor. 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-24)
      Cellular stress response mechanisms typically increase organellar quantity and volume. To restore cellular homeostasis and organellar integrity, the surplus organelles are cleared by macroautophagy/autophagy, an intracellular process that shuttles cytoplasmic material to the lysosomes for degradation. The degradation is mediated by autophagy receptors that selectively link the degradable cargo to ...